Recent questions tagged pharmacology

by trupti chikram asked Jul 25, 2021 0 views

Cyclosporine has the following attributes except: A. It selectively suppresses humoral immunity without affecting cell mediated immunity B. It is more active as immunosuppressant when administered before antigen exposure ... It is not toxic to the bone marrow D. Its major toxicity is kidney damage
Answer : A. It selectively suppresses humoral immunity without affecting cell mediated immunity...

by trupti chikram asked Jul 25, 2021 0 views

Select the drug which is used exclusively in organ transplantation and autoimmune diseases, but not in cancers: A. Cyclophosphamide B. Cyclosporine C. Methotrexate D. 6-Mercaptopurine
Answer : B. Cyclosporine...

by trupti chikram asked Jul 25, 2021 0 views

What is true of thalidomide: A. It exerts antitumour activity in some solid malignant tumours B. It ameliorates cancer associated cachexia C. It exerts antileprotic action D. All of the above
Answer : B. It ameliorates cancer associated cachexia...

by trupti chikram asked Jul 25, 2021 0 views

Biological response modifiers like GM-CSF are used in conjunction with anticancer drugs for the following purpose(s): A. To enhance antitumour activity of the drug B. To prevent hypersensitivity reactions to ... . To hasten recovery from drug induced myelosuppression D. Both A' and C' are correct
Answer : C. To hasten recovery from drug induced myelosuppressio...

by trupti chikram asked Jul 25, 2021 0 views

Mesna is administered with cyclophosphamide and ifosphamide to: A. Potentiate their cytotoxic action B. Retard their renal excretion C. Block their emetic action D. Ameliorate cystitis caused by them
Answer : D. Ameliorate cystitis caused by them...

by trupti chikram asked Jul 25, 2021 0 views

Select the cell cycle nonspecific antineoplastic drug: A. Vincristine B. Bleomycin C. Methotrexate
Answer : D. 5-Fluorouracil...

by trupti chikram asked Jul 25, 2021 0 views

The following does not apply to cancer chemotherapy: A. Each treatment with a cytotoxic drug kills a constant number of malignant cells B. Drugs are generally used at maximum tolerated ... D. Combination regimens using several drugs in succession are superior to single drug used continuously
Answer : A. Each treatment with a cytotoxic drug kills a constant number of malignant cells...

by trupti chikram asked Jul 25, 2021 0 views

The following is true about use of prednisolone in malignant diseases except: A. It is curative in acute childhood leukaemia B. It is used in Hodgkin’s disease C. It controls hypercalcaemia in patients with bony metastasis D. It affords symptomatic relief in most cancer patients
Answer : A. It is curative in acute childhood leukaemia...

by trupti chikram asked Jul 25, 2021 0 views

Patients treated with the following anticancer drug are likely to develop a disulfiram like reaction on taking alcohol: A. Dacarbazine B. Procarbazine C. Melphalan D. Hydroxyurea
Answer : B. Procarbazine...

by trupti chikram asked Jul 25, 2021 0 views

Thioguanine differs from mercaptopurine in that: A. It is not metabolized by xanthine oxidase B. It does not cause hyperuricemia C. Its dose need not be reduced when allopurinol is given concurrently D. Both ‘A’ and ‘C’ are correc
Answer : D. Both ‘A’ and ‘C’ are correct...

by trupti chikram asked Jul 25, 2021 0 views

The characteristic toxicity of doxorubicin is: A. Kidney damage B. Liver damage C. Cardiomyopathy D. Pulmonary fibrosis
Answer : C. Cardiomyopathy...

by trupti chikram asked Jul 25, 2021 1 view

Choose the correct statement about topotecan: A. It is a DNA topoisomerase I inhibitor which causes single strand DNA breaks B. It is a cell cycle specific anticancer drug C. It is a COMT-inhibitor used in advanced parkinsonism D. Both 'A' and 'B' are correc
Answer : D. Both 'A' and 'B' are correct...

by trupti chikram asked Jul 25, 2021 0 views

What is true of docetaxel: A. It is used as a reserve drug for refractory breast and ovarian cancer B. It is a selective estrogen receptor modulator used for breast cancer C. It is effective only in estrogen receptor positive breast cancer D. Both 'B' and 'C' are correct
Answer : A. It is used as a reserve drug for refractory breast and ovarian cancer...

by trupti chikram asked Jul 25, 2021 0 views

Vincristine differs from vinblastine in the following respect(s): A. Its prominent adverse effect is neuropathy B. It frequently produces alopecia C. It does not significantly depress bone marrow D. All of the above
Answer : D. All of the above...

by trupti chikram asked Jul 25, 2021 1 view

The following cytotoxic drug acts by inhibiting depolymerization of tubulin and thus producing abnormal arrays of microtubules: A. Paclitaxel B. Vinblastine C. Etoposide D. Mitoxantrone (p. 774) 60.9 C 60.10 B 60.11 D 60.12 A Ai
Answer : A. Paclitaxel...

by trupti chikram asked Jul 25, 2021 2 views

Vinca alkaloids exert antitumor activity by: A. Activating topoisomerase II to cause breaks in DNA strands B. Crosslinking DNA strands C. Inhibiting DNA mediated RNA synthesis D. Inhibiting polymerization of tubulin to form intracellular microtubules
Answer : D. Inhibiting polymerization of tubulin to form intracellular microtubules...

by trupti chikram asked Jul 25, 2021 0 views

The following antineoplastic drug is a mitotic inhibitor and causes metaphase arrest: A. Busulfan B. Vincristine C. Cytarabine D. Procarbazine
Answer : B. Vincristine...

by trupti chikram asked Jul 25, 2021 0 views

Methotrexate has the following attributes except: A. It is cell cycle specific and kills cells in the S phase B. Its toxicity primarily affects bone marrow and epithelial structures C. Folic acid reverses its toxic effects D. It is the drug of choice for choriocarcinoma
Answer : C. Folic acid reverses its toxic effects...

by trupti chikram asked Jul 25, 2021 0 views

The most important target of action of chlorambucil is: A. Myeloid tissue B. Lymphoid tissue C. Neural tissue D. Skin
Answer : B. Lymphoid tissue...

by trupti chikram asked Jul 25, 2021 0 views

The following is true of cyclophosphamide except: A. It is highly reactive and a vesicant on contact B. It is a prodrug C. It has marked immunosuppressant property D. It frequently causes alopecia and cystitis
Answer : A. It is highly reactive and a vesicant on contac...