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A patient of megaloblastic anaemia was treated with oral folic acid 5 mg daily. After 2 weeks he reported back with cognitive deficit, sensory disturbance, depressed knee jerk, while blood picture and haemoglobin level were improved. What could be the most likely explanation: A. Folic acid was not adequately absorbed resulting in partial response B. Folate therapy has precipitated vitamin B12 deficiency in the neural tissue C. Folate therapy has unmasked pyridoxine deficiency D. Patient has folate reductase abnormality in the nervous system

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A patient of megaloblastic anaemia was treated with
oral folic acid 5 mg daily. After 2 weeks he reported
back with cognitive deficit, sensory disturbance,
depressed knee jerk, while blood picture and haemoglobin level were improved. What could be the most
likely explanation:
A. Folic acid was not adequately absorbed resulting in partial response
B. Folate therapy has precipitated vitamin B12
deficiency in the neural tissue
C. Folate therapy has unmasked pyridoxine
deficiency
D. Patient has folate reductase abnormality in
the nervous system
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1 Answer

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D. Patient has folate reductase abnormality in
the nervous system
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