In many types of cancer, proteins that are crucial regulators of the cell cycle are often mutated and cannot function correctly. This leads to the evasion of apoptosis and to the loss of control of cell proliferation? For example, many cancer cells carry two mutant copies of the gene that codes for a tumor suppressor protein named p53. What is the normal function of p53 that is lost when it is mutated?

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In many types of cancer, proteins that are crucial regulators of the cell cycle are often mutated and cannot function correctly. This leads to the evasion of apoptosis and to the loss of control of cell proliferation? For example, many cancer cells carry two mutant copies of the gene that codes for a tumor suppressor protein named p53. What is the normal function of p53 that is lost when it is mutated?

by itszee asked Jul 18, 2021 1 view

In many types of cancer, proteins that are crucial regulators of the cell cycle are
often mutated and cannot function correctly. This leads to the evasion of apoptosis
and to the loss of control of cell proliferation? For example, many cancer cells carry
two mutant copies of the gene that codes for a tumor suppressor protein named p53.
What is the normal function of p53 that is lost when it is mutated?

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itszee · Answer 1 · 2021-07-18T14:23:38+0000

Normally, p53 senses DNA damage and acts as a transcription factor for checkpoint
control genes.

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