How do RTKs function?

What types of signaling molecules bind to and activate RTKs?
Answer : Growth factors, hormones, some extracellular matrix proteins, some cell surface proteins (i.e. ephrin)...

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by itszee asked Jul 18, 2021 0 views

List several general cellular processes regulated by receptor tyrosine kinases (RTKs).

List several general cellular processes regulated by receptor tyrosine kinases (RTKs).
Answer : Cell growth, cell differentiation and cell survival (i.e. nutrient and stress signaling)....

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by itszee asked Jul 18, 2021 1 view

Multiple checkpoints in the eukaryotic cell cycle ensure that division occurs only after sufficient growth and faithful DNA replication, and only when favorable conditions exist. Of the many proteins involved in cell cycle control, cyclin-dependent kinases (CDKs) are among the most important. How do CDKs function to control the cell cycle?

Multiple checkpoints in the eukaryotic cell cycle ensure that division occurs only after sufficient growth and faithful DNA replication, and only when favorable conditions exist. Of the many proteins involved in ... CDKs) are among the most important. How do CDKs function to control the cell cycle?
Answer : CDKs phosphorylate various protein substrates that are required for cell cycle progression. Some of the important substrate proteins that CDKs phosphorylate include condensin proteins, which are essential ... which form a stabilizing network under the nuclear membrane that assembles during mitosis....

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by itszee asked Jul 18, 2021 2 views

In order to function, CDKs must interact with members of a separate family of proteins named the cyclins. Do individual cyclins remain associated with the same CDKs throughout the entire cell cycle?

In order to function, CDKs must interact with members of a separate family of proteins named the cyclins. Do individual cyclins remain associated with the same CDKs throughout the entire cell cycle?
Answer : No. Separate cyclins interact with specific CDKs only during defined periods of the cell cycle....

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itszee · Answer 1 · 2021-07-18T13:32:16+0000

Activating signaling molecules (ligands, agonists) bind to RTKs, causing neighboring
RTKs to form cross-linked dimers. Cross-linking leads to tyrosine kinase activation
via cross-phosphorylation. Once activated, TKRs stimulate an enzymatic cascade of
reactions that ultimately lead to changes in the patterns of gene transcription.

How do RTKs function?

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