How do RTKs function? Answer : Activating signaling molecules (ligands, agonists) bind to RTKs, causing neighboring RTKs to form cross-linked dimers. Cross-linking leads to tyrosine kinase activation via cross-phosphorylation. Once ... cascade of reactions that ultimately lead to changes in the patterns of gene transcription....
How do RTKs differ from other cell surface receptors? Answer : RTKs are receptors that contain intrinsic enzyme (tyrosine kinase) activity....
List several general cellular processes regulated by receptor tyrosine kinases (RTKs). Answer : Cell growth, cell differentiation and cell survival (i.e. nutrient and stress signaling)....
What are integrins and do they influence cell-cell signaling? Answer : Integrins are a diverse family of transmembrane proteins consisting of alpha and beta subunits that are found in all animal cells. Integrins link the actin cytoskeleton to the ... movement, and can thus influence actin cytoskeleton dynamics and intracellular signaling of neighboring cells....
What are gap junctions and how do they contribute to cell-cell signaling? Answer : Gap junctions are specialized connections that form a pore between adjacent cells, which permit small molecules and ions to move from one cell to another. In this way, gap junctions provide metabolic and electrical coupling between cells....
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