Describe how proteins that are synthesized in the endoplasmic reticulum (ER) are
transported to their final destination.
transported to their final destination.
1 Answer
Proteins that are synthesized in the ER have a signal sequence that directs them to
their target destination. Soluble proteins are carried inside the lumen of vesicles.
Cargo-bearing vesicles pinch off of one set of membranes and travel along
microtubule tracks to fuse with the next set of membranes. Trafficking can occur in
both directions; the forward direction takes vesicles from the site of synthesis to the
Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that
have released their cargo return via the reverse direction.
their target destination. Soluble proteins are carried inside the lumen of vesicles.
Cargo-bearing vesicles pinch off of one set of membranes and travel along
microtubule tracks to fuse with the next set of membranes. Trafficking can occur in
both directions; the forward direction takes vesicles from the site of synthesis to the
Golgi apparatus and next to a cell's lysosomes or plasma membrane. Vesicles that
have released their cargo return via the reverse direction.